Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis
نویسندگان
چکیده
منابع مشابه
Neutrophil Extracellular Traps in Ulcerative Colitis: A Proteome Analysis of Intestinal Biopsies
BACKGROUND The etiology of the inflammatory bowel diseases, including ulcerative colitis (UC), remains incompletely explained. We hypothesized that an analysis of the UC colon proteome could reveal novel insights into the disease etiology. METHODS Mucosal colon biopsies were taken by endoscopy from noninflamed tissue of 10 patients with UC and 10 controls. The biopsies were either snap-frozen...
متن کاملThe Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases.
Neutrophil pathogen-killing mechanism termed neutrophil extracellular traps (NETs) has been recently identified. NETs consist of chromatin and histones along with serine proteases and myeloperoxidase and are induced by a great variety of infectious and non-infectious stimuli. NETosis is a kind of programmed neutrophil death characterized by chromatin decondensation and release of nuclear granul...
متن کاملNeutrophil extracellular traps
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.
متن کاملNeutrophil extracellular traps
Coming soon to a doctor’s surgery near you? Hopes placed on the sequencing of ‘the’ human genome and the subsequent identification of many single-nucleotide polymorphisms (SNPs) have turned out to be misguided, as the causes of common diseases like cancer and heart disease have proven too complex to be addressed with simple SNP searches. Also, large-scale genomic differences like copy number va...
متن کاملRole of MicroRNAs in BCG Therapy by the Induction of Neutrophil Extracellular Traps in Bladder Cancer
The treatment of bladder cancer is usually performed by Bacillus Calmette-Guerin (BCG) instillation. BCG therapy is a common therapeutic method with fewer side effects compared with chemotherapy, radiotherapy, etc. BCG can also inhibit the progression and recurrence of bladder cancer by inducing apoptosis pathways, arrest cell cycle, autophagy, and neutrophil extracellular traps (NETs) formatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2019
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjy215